diff --git a/setup.py b/setup.py
index 761d552..4ddc598 100755
--- a/setup.py
+++ b/setup.py
@@ -136,12 +136,12 @@ except (ImportError, OSError):
 
 NAME = 'Pillow'
 PILLOW_VERSION = get_version()
-JPEG_ROOT = None
+JPEG_ROOT = tuple(os.environ['JPEG_ROOT'].split('|')) if 'JPEG_ROOT' in os.environ else None
 JPEG2K_ROOT = None
-ZLIB_ROOT = None
+ZLIB_ROOT = tuple(os.environ['ZLIB_ROOT'].split('|')) if 'ZLIB_ROOT' in os.environ else None
 IMAGEQUANT_ROOT = None
 TIFF_ROOT = None
-FREETYPE_ROOT = None
+FREETYPE_ROOT = tuple(os.environ['FREETYPE_ROOT'].split('|')) if 'FREETYPE_ROOT' in os.environ else None
 LCMS_ROOT = None
 
 
@@ -194,7 +194,7 @@ class pil_build_ext(build_ext):
     ]
 
     def initialize_options(self):
-        self.disable_platform_guessing = None
+        self.disable_platform_guessing = True
         build_ext.initialize_options(self)
         for x in self.feature:
             setattr(self, 'disable_%s' % x, None)
@@ -466,61 +466,6 @@ class pil_build_ext(build_ext):
                     feature.jpeg = "libjpeg"  # alternative name
 
         feature.openjpeg_version = None
-        if feature.want('jpeg2000'):
-            _dbg('Looking for jpeg2000')
-            best_version = None
-            best_path = None
-
-            # Find the best version
-            for directory in self.compiler.include_dirs:
-                _dbg('Checking for openjpeg-#.# in %s', directory)
-                try:
-                    listdir = os.listdir(directory)
-                except Exception:
-                    # WindowsError, FileNotFoundError
-                    continue
-                for name in listdir:
-                    if name.startswith('openjpeg-') and \
-                        os.path.isfile(os.path.join(directory, name,
-                                                    'openjpeg.h')):
-                        _dbg('Found openjpeg.h in %s/%s', (directory, name))
-                        version = tuple(int(x) for x in name[9:].split('.'))
-                        if best_version is None or version > best_version:
-                            best_version = version
-                            best_path = os.path.join(directory, name)
-                            _dbg('Best openjpeg version %s so far in %s',
-                                 (best_version, best_path))
-
-            if best_version and _find_library_file(self, 'openjp2'):
-                # Add the directory to the include path so we can include
-                # <openjpeg.h> rather than having to cope with the versioned
-                # include path
-                # FIXME (melvyn-sopacua):
-                # At this point it's possible that best_path is already in
-                # self.compiler.include_dirs. Should investigate how that is
-                # possible.
-                _add_directory(self.compiler.include_dirs, best_path, 0)
-                feature.jpeg2000 = 'openjp2'
-                feature.openjpeg_version = '.'.join(str(x) for x in best_version)
-
-        if feature.want('imagequant'):
-            _dbg('Looking for imagequant')
-            if _find_include_file(self, 'libimagequant.h'):
-                if _find_library_file(self, "imagequant"):
-                    feature.imagequant = "imagequant"
-                elif _find_library_file(self, "libimagequant"):
-                    feature.imagequant = "libimagequant"
-
-        if feature.want('tiff'):
-            _dbg('Looking for tiff')
-            if _find_include_file(self, 'tiff.h'):
-                if _find_library_file(self, "tiff"):
-                    feature.tiff = "tiff"
-                if sys.platform == "win32" and _find_library_file(self, "libtiff"):
-                    feature.tiff = "libtiff"
-                if (sys.platform == "darwin" and
-                        _find_library_file(self, "libtiff")):
-                    feature.tiff = "libtiff"
 
         if feature.want('freetype'):
             _dbg('Looking for freetype')
@@ -546,36 +491,6 @@ class pil_build_ext(build_ext):
                     if subdir:
                         _add_directory(self.compiler.include_dirs, subdir, 0)
 
-        if feature.want('lcms'):
-            _dbg('Looking for lcms')
-            if _find_include_file(self, "lcms2.h"):
-                if _find_library_file(self, "lcms2"):
-                    feature.lcms = "lcms2"
-                elif _find_library_file(self, "lcms2_static"):
-                    # alternate Windows name.
-                    feature.lcms = "lcms2_static"
-
-        if feature.want('webp'):
-            _dbg('Looking for webp')
-            if (_find_include_file(self, "webp/encode.h") and
-                    _find_include_file(self, "webp/decode.h")):
-                # In Google's precompiled zip it is call "libwebp":
-                if _find_library_file(self, "webp"):
-                    feature.webp = "webp"
-                elif _find_library_file(self, "libwebp"):
-                    feature.webp = "libwebp"
-
-        if feature.want('webpmux'):
-            _dbg('Looking for webpmux')
-            if (_find_include_file(self, "webp/mux.h") and
-                    _find_include_file(self, "webp/demux.h")):
-                if (_find_library_file(self, "webpmux") and
-                        _find_library_file(self, "webpdemux")):
-                    feature.webpmux = "webpmux"
-                if (_find_library_file(self, "libwebpmux") and
-                        _find_library_file(self, "libwebpdemux")):
-                    feature.webpmux = "libwebpmux"
-
         for f in feature:
             if not getattr(feature, f) and feature.require(f):
                 if f in ('jpeg', 'zlib'):
@@ -612,8 +527,6 @@ class pil_build_ext(build_ext):
             defs.append(("HAVE_LIBTIFF", None))
         if sys.platform == "win32":
             libs.extend(["kernel32", "user32", "gdi32"])
-        if struct.unpack("h", "\0\1".encode('ascii'))[0] == 1:
-            defs.append(("WORDS_BIGENDIAN", None))
 
         if sys.platform == "win32" and not (PLATFORM_PYPY or PLATFORM_MINGW):
             defs.append(("PILLOW_VERSION", '"\\"%s\\""' % PILLOW_VERSION))
@@ -658,10 +571,6 @@ class pil_build_ext(build_ext):
                                   define_macros=defs))
 
         tk_libs = ['psapi'] if sys.platform == 'win32' else []
-        exts.append(Extension("PIL._imagingtk",
-                              ["src/_imagingtk.c", "src/Tk/tkImaging.c"],
-                              include_dirs=['src/Tk'],
-                              libraries=tk_libs))
 
         exts.append(Extension("PIL._imagingmath", ["src/_imagingmath.c"]))
         exts.append(Extension("PIL._imagingmorph", ["src/_imagingmorph.c"]))
